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Description

A detoxification gene linked to the secretion tag of our construct would theoretically allow the enzyme to be produced and transported out of the cell into the bee gut, which is the principal location of bee insecticide metabolism [1]

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This is a scenario which overstresses the remaining beta cells, which are still capable of providing insulin in the diabetic metabolic state and thus gives rise also to more misfolded proinsulin (Lenzen 2017)

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It was also clear that expression of the immune-related genes pirk and PGRP-LB were decreased by MetR, suggesting attenuation of the inflammatory state in the aged gut (Fig

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S5, S6A, S6B)

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