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doi: 10.1152/ajpregu.00428.2006 110 AfonsoRALauttWWSchaferJLegareDJOliveiraAGMacedoMP

New insights on the effects of Withania somnifera on the motivational properties of addictive drugs

In astrocytes, glutamine (Gln), the major precursor of Glu, is synthesized via Gln synthetase and transferred to neurons, where it is converted back into Glu by phosphate-activated glutaminase, further entering mitochondrial pathways