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Furthermore, extensive research suggests that OS may impact cognitive function through various pathways, such as directly damaging parvalbumin-expressing interneurons (PVIs) (Schiavone et al., 2009), hindering oligodendrocyte precursor cell (OPC) proliferation and myelin formation in the prefrontal cortex (PFC) (Maas et al., 2021), disrupting the bloodbrain barrier (BBB) (Geng et al., 2023), and inducing mitochondrial dysfunction (Fizikova et al., 2023)

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Over a 180-day follow-up period, 3,371 individuals (8%) received any AUD treatment, 2,393 (6%) received pharmacotherapy alone, and 215 (0.5%) received both behavioral and pharmacotherapy

In this respect, underweight mothers with a BMI 30 kg/m 2 are at risk of macrosomia and gestational diabetes (252)