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Figure showing a Secundum Atrial Septal Defect Since the pressure difference between the two atria is small, no turbulence is generated by the flow across the ASD

For example, one insurance claimsbased study reported that individuals with endometriosis have significantly elevated odds of co-occurring chronic pain conditions, including a 15.6-fold increase for vulvodynia, 18.6-fold for irritable bowel syndrome, 10-fold for fibromyalgia, fivefold for interstitial cystitis/bladder pain syndrome, and 3.2-fold for migraine headaches

Other works from the same group later identified that functional AR was protective against obese phenotypes, where ARKO male mice had increased body mass, skeletal muscle triglycerides, relative WAT mass, and WAT CSA in adulthood [194], as well as increased WAT and BAT adipocyte size at 12-weeks of age [197]

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