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In addition, the prostate of T-BPH rats showed significantly accelerated proliferation activity, shortened cell cycle, decreased apoptosis, and up-regulated ferroptosis, OS and autophagy levels, which were consistent with what we observed in human hyperplastic prostate

Hence, L-lactate metabolism in mitochondria is likely to produce partial ROS and then activate its related signals if there exists analogous oxidase located at the mitochondrial inner membrane in the neurons

The review was conducted under Project Orbis, the FDAs framework for concurrent international oncology review, alongside partner agencies from Australia, Brazil, Canada, Singapore, and Switzerland

Author Contributions Concept and design: Eunhee Choi Acquisition, analysis, or interpretation of data: Eunhee Choi, Laverne Yip, Krishna Kishore Anna, Gabriela Galicia Garcia, Maria F

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