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This study was supported by grants from the Tokyo Metropolitan Government and Japan Agency for Medical Research and Development (24015981, 25fk0210143h0002, 25130307, 25fk0310544s0201 and JP253fa827017)

While both physical activity and cognitive exercises have established benefits, VR uniquely supports their integration within ecologically valid, adaptive environments

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In CRC, many ferroptosis pathways are mediated through lipid metabolism regulators, such as SCD-1, CPT1, and CD36, suggesting that lipid metabolism is closely related to ferroptosis [91, 143,144,145]

210 However, the efficacy of FMT is not universally consistent and faces significant challenges