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In response to SASP, macrophages are recruited into the articular space and secrete proinflammatory factors to activate synovial fibroblasts, which promote osteophyte formation and further exacerbating osteoarthritis [140]

The extreme cold triggers a surge of catecholamines, hormones that act as neurotransmitters, activating the body's fight-or-flight response, Brecka explained

It is well known that long-term inflammation could cause cardiac remodeling due to fibrosis, ultimately leading to heart failure or arrhythmia (Korompoki et al., 2021)