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doi: 10.1074/jbc.M211609200 31 BruniL.PastorelliR.VitiC.GascoL.ParisiG

Many diseases with a neurological component, such as MS and Parkinsons caused patients brains to shrink and contract

Jin, J., Sklar, G

This may include using insulated containers with ice packs or cool packs, though direct contact between the medication and ice should be avoided to prevent freezing