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Pharmacol., 44: 1193-1193

SCFAs are synthesized predominantly in the cecum and ascending colon, where they play roles in modulating food absorption, altering the gut pH, supporting immune function, and maintaining overall gastrointestinal health and stability (Litvak et al., 2018)

The other pathway converts homocysteine to another amino acid, cysteine, and requires two vitamin B 6 -dependent enzymes

Elucidating how mtDNA alterations engage these layers in a context-dependent manner will be critical for defining when metabolic and immunologic rewiring promotes immune evasion versus antitumor immunity