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Similarly, in chronic myeloid leukaemia (CML), co-inhibition of Trx1 and glutamate-cysteine ligase may serve as a therapeutic strategy for both imatinib-sensitive and drug-resistant patients by triggering ferroptosis (75)

Many factors can deplete the amount of glutathione in your body, including pollution, stress, infections, poor sleep, a diet low in plant foods, and even simply becoming older, as youll make less of this valuable antioxidant as you age

It has been extensively studied in preclinical models for its healing and cytoprotective properties

The function of any of these tissue-specific proteins can be altered by single nucleotide polymorphisms (SNPs) in any individual

Radiother Oncol 146:200-204, 2020