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To this end, we also consider the concept of bet hedging and fluctuating environmentsnamely, that different phenotypes in a population will have varying degrees of fitness to any specific environment, potentially lowering the overall population fitness but ensuring the existence of some individuals favorably adapted to an altered environment

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In a recent study, Liskiewicz and colleagues discovered that long-acting GIP receptor agonists activate GABAergic neurons that express the GIP receptor in the area postrema, and that GIP receptor signaling in GABAergic neurons is necessary for the effects of GIP to lower body weight [151]