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The cytochrome P450 enzyme CYP1B1, an extrahepatic isoform involved in arachidonic acid metabolism in the brain cortex and cerebellum, is abundantly expressed in brain microvascular endothelial cells, comprising 77% of CYP isoforms in the brain microvasculature [142,143,144,145]

100% Safety Profile: The study recorded zero adverse events , confirming that copper peptides provide a powerful, non-irritating alternative to traditional chemical treatments

Tyrosinase plays a key role in melanin production

Limitations This study could not assess melasma area severity index score as mesotherapy was applied only on cheeks of the patients

2013;2(6):e000364