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doi: 10.1016/j.amjcard.2013.09.021 3 AokiK.UchiharaT.SanjoN.NakamuraA.IkedaK.TsuchiyaK.et al

are members of IGradU

Benefit duration remains a major concern

Rational combinations of third-generation EGFR TKIs with anti-angiogenic drugs, chemotherapy, the EGFRMET bispecific antibody amivantamab or local tumour ablation are under investigation as strategies to delay resistance, prolong the duration of response and maximize treatment efficacy