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( F ) The mRNA level of RSMC was checked by qRT-PCR and compared to the GAPDH control

Among all phase I drug-metabolizing enzymes, cytochrome P450 enzymes (CYPs) play a key role in the metabolism of ACDs

[DOI] [PubMed] [Google Scholar] 34.Jungsuwadee P, Cole MP, Sultana R, Joshi G, Tangpong J, Butterfield DA, et al

In addition, cholestatic liver injuries such as primary biliary cirrhosis and primary sclerosing cholangitis can also lead to an increase in AREG expression to protect hepatocytes from injury (Santamara et al., 2019)