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Abbreviations AAI: Antioxidant activity index ABTS: (2,2-Azino-Bis (3-Ethylbenzothiazoline-6-Sulfonic Acid) ALT: L-Alanine transaminase AST: L-Aspartate transaminase ATCC: American type culture collection BHA: (2,3-Tert-Butyl-4-HydroxyAnisole) BHT: Butylated hydroxytoluene CD: Circular dichroism CFU: Colony-forming units CUPRAC: Cupric ions Cu 2+ Reducing antioxidant power DMBA: 7,1 2-Dimethyl-benzo anthracene DPPH: 2,2-Diphenyl-1-picrylhydrazyl DTA: Differential thermal analysis DXR: Doxorubicin ESI-EM: Electrospray ionization Fe 2+ TPTZ: Ferrous tripyridyltriazine complex Fe 3+ TPTZ: Ferric tripyridyltriazine complex FRAP: Ferric reducing/antioxidant power GPx: Glutathione peroxidases HA: Hydrochloric acid HB: High bioactivation cross HPLC: High performance liquid chromatography HPLCDAD: High liquid chromatography performance coupled to diode array detector IC 50 : Median inhibition concentration LCMS: Liquid chromatography with mass spectrometry MDA: Malon dialdehyde MeOH: Methanol MIC: Minimal inhibitory concentration MS: Mass spectrometry MTT: (3-(4,5-Dimethylthiazol-2yl)-2,5-diphenyl tetrazoline bromide) n-BuOH: Butanol NMR: Nuclear magnetic resonance NO: Nitric oxide ODS: Octadecyl silica gel ORAC: Oxygen radical absorbance capacity PYR-CG/MS: Pyrolysis coupled to gas chromatography and mass spectrometry SMART: Somatic mutation and recombination test SNP: Sodium nitroprusside SOD: Superoxide dismutase ST: Standard crossing TEAC: Trolox equivalent antioxidant capacity TEAC: Trolox equivalent antioxidant capacity TGF-1: Transforming growth factor TLC: Thin layer chromatography TRAP: Total radical -trapping antioxidant parameter UV: Ultraviolet radiation ZI: Zone of inhibition References Adewale OO, Oduyemi OI, Ayokunle O (2014) Oral administration of leaf extracts of Momordica charantia affectreproductive hormones of adult female Wistar rats

Oxidation of methionine was set as a variable