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31,32 Considering this information, the natural history of cNF is poorly understood for multiple reasons: patients can develop many cNFs throughout life, cNF burden varies greatly among NF1 patients and the precise sequence and nature of all cNF-initiating events is unknown

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Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an autosomal dominant inherited disease that originates from germ-line mutations in the fumarate hydratase (FH) gene

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In systemic lupus erythematosus (SLE), which is characterized by chronic activation of self-reactive lymphocytes and myeloid cells, untargeted lipidomics using LC/MS and GC/MS has revealed altered serum concentrations of choline, ACh, phosphocholine, and specific species of PC, lysoPC, and sphingomyelin (192194)

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