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Since inhibition of Topoisomerase I might lead to DNA damage, we assessed the levels of p53 phosphorylation on Ser15 [a residue that can be phosphorylated by ATM/ATR 25 ] and found that indeed parental and resistant cells treated with T-DXd display this post-translational modification (Fig

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Increasing the total productivity of a land by combining mobile photovoltaic panels and food crops

Results of the 16-week double-blind, placebo-controlled randomized controlled trial show that Gly-NAC supplementation significantly improved glutathione concentrations and reduced oxidative stress and inflammatory markers in older adult subjects