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In FRDA, however, this defense system breaks down at the genetic level

A TAZ-ANGPTL4-NOX2 Axis regulates ferroptotic cell death and chemoresistance in epithelial ovarian cancer

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Studies have shown that in the absence of GPX4, the calcium-independent phospholipase iPLA2 acts as a major ferroptosis suppressor in a GPX4-independent manner (Chen et al