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Early sterol biosynthesis genes, such as the steroid reductase DET2, were up-regulated in SL compared with galls (Fig

also suggests that the peptide may upregulate VEGF, increase endothelial cell proliferation, and promote endothelial migration and tube formation

Notably, BPC 157 may scavenge reactive oxygen species due to its structure: it contains four carboxylic groups, and when they are reactivated (by glutathione or enzymes), the antioxidant activity is very high

CRISPR/Cas9-mediated knockout of Lcn2 in human breast cancer cell line MDA-MB-231 ameliorates erastin-mediated ferroptosis and increases cisplatin vulnerability

Heneka et al., 2025)