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Zenk, M

doi: 10.1016/S1074-7613(00)80168-5 23 GuexNPeitschMC

Lysine-specific histone demethylase 1B (LSD2/KDM1B) represses p53 expression to promote proliferation and inhibit apoptosis in colorectal cancer through LSD2-mediated H3K4me2 demethylation

that is, when pharmacokinetics are linear. In this situation, when the drug is eliminated (ie, metabolized and excreted from the body), the fall in blood level is proportionate to the concentration of the drug in blood