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Since the low concentrations of cobalamin in our subjects were found as part of a screening program, in the absence of specific clinical symptoms, we assume that the subjects were at an early stage of negative cobalamin balance [16]

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One posited mechanism is the activation of phospholipase C (PLC), which, according to some researchers, might subsequently facilitate the release of inositol triphosphate (IP3) and diacylglycerol (DAG)