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Funding This work was fund by the project of CAMS Innovation Fund for Medical Sciences (2016-I2M-3-005)

Fibronectin can regulate the activation and function of immune cells by interacting with receptors on glial cells, such as Cluster of Differentiation 44 (CD44) and Purinergic Receptor P2Y2 (P2Y2), thereby affecting neuroinflammation and neuroprotection ( 3 The role of glial cells in ferroptosis during Parkinson's disease 3.1 Mechanisms underlying ferroptosis-induced Parkinsons disease Iron is essential for cell development and maintaining various physiological processes in the central nervous system