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Migliavacca Center for Liver Disease, Department of Pathophysiology and Transplantation, University of Milan Background: In patients with primary biliary cholangitis (PBC), quantitative assessment of anti-mitochondrial antibodies (AMA)-M2 is currently available, however its clinical meaning is still unknown

Highly plasma protein bound drugs are confined to the vascular space, thereby having a relatively low volume of distribution

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Both HCQ and CQ are immunomodulatory drugs and have the potential to suppress normal immune system activation

Ruiz, Drug release, in ADME Processes in Pharmaceutical Sciences: Dosage, Design, and Pharmacotherapy