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Hyaluronic acid is a natural compound found in skin that has many important functions, including holding in moisture, providing cushioning, aiding in tissue repair, holding together the skin structural components collagen and elastin

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Eisenberg MA, Deboever N, Hofstetter WL, Mehran RJ, Rice DC, Rajaram R, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Antonoff MB

Padmanabhan Seshaiyer 26

Although some transcriptomic rewiring might be caused by general stress signalling associated with tumour growth, 120 exposure to various microenvironmental factors, such as signalling molecules, stromal cells, metabolites or hypoxia couldin a premetastatic but already advanced cancer cellinduce stable transcriptional responses that eventually increase metastatic fitness