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Moreover, a high-fat diet exacerbates oxidative stress in ocular surface epithelial cells, increasing the expression of enzymes like NOX4 and markers of nitrosative stress such as 3-nitrotyrosine (3-NT) [139]

At doses above 1500mg per day studies suggest it may be helpful in people with neuropathy.

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Future studies should aim to clarify the molecular pathways that link nutrient metabolism to issues and the application of these findings for personalized treatments

166 Another placebo-controlled trial in 14 elderly participants with self-reported poor sleep found 405 mg valerian extract three times daily for seven days increased slow-wave sleep as assessed with polysomnography