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Description

Senolytic agents include natural compounds such as quercetin 13 or fisetin 14 , -galactosidase-activated nanoparticles and prodrugs 15,16,17 or compounds that target different vulnerabilities of senescent cells, such as HSP90 inhibitors 18 , cardiac glycosides 19,20 or NMT inhibitors 21

10.1073/pnas.90.8.3569 97 GolubnitschajaO.DebaldM.YeghiazaryanK.KuhnW.PetaM.CostigliolaV.et al (2016)

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These compounds signal fibroblasts and endothelial cells to rebuild connective tissue and increase blood vessel formation, leading to faster wound healing and stronger tissue integrity