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An important note on folate: if B12 deficiency is suspected, folate deficiency should not be corrected in isolation before B12 status has been assessed and treated, as doing so can precipitate or worsen neurological complications

Glutathione depletion and a corresponding increase in reactive oxygen species (ROS) during microbial infection is a key driver of the immune response and inflammation

J Pineal Res 60(4):405414 Shi CS, Nabar NR, Huang NN, Kehrl JH (2019) SARS-coronavirus open reading frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes

doi: 10.1111/j.1478-3231.2008.01770.x

There are multiple sites that face the external environment, including mucosal surfaces of the respiratory, urinary, and GI tracts, as well as the skin