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13 These studies collectively construct a framework of altered microbial compositionmetabolic dysfunctionhepatic pathological response, positioning the gut microbiota as a core regulator of liver disease progression

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Hoechst staining Hoechst 33342 was used to specifically stain the nuclei of living and fixed cells and tissues, which allowed for the measurement of apoptosis within cells

Medicine 96(39):e8179

Mechanisms of epigenetic modifications The epigenetic modifications can be generally categorized into three groups: DNA and RNA methylations, histone modifications, and non-coding RNAs, which are considered as main mechanisms of regulation during carcinogenesis/cancer progression