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Elucidating the mechanisms of toxicity and probable susceptibility factors which make patients vulnerable to DILI, will lead us to the safer pharmaceuticals development and reducing adverse drug reactions (ADRs)

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The human body naturally produces hundreds of distinct peptides that regulate virtually every physiological function including growth hormone release, immune activity, tissue repair, inflammation resolution, metabolism, pain modulation, neurotransmitter balance, and cardiovascular function

Importantly, sustained cortisol elevation can suppress the HPT axis by inhibiting TRH expression, reducing TSH secretion, and impairing deiodinase activity, which not only blunts thyroid hormone production but may also raise rT3 levels and exacerbate functional hypothyroidism in susceptible individuals

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