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10.1016/j.bbamem.2006.09.002 89 PalmadaM.SpeilA.JeyarajS.BhmerC.LangF

Two main hypotheses can be raised to explain lower efficacy of second-line medications [5]: either therapeutic failure is predominantly a marker of severity regardless of the sequence or the use of the first-line biologic is dramatically changing the immune system response [23] limiting the efficacy of a second therapy meaning that therapeutic sequencing is crucial and highly condition the long-term outcomes of patients with UC