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Single interventions, including psychology, physiotherapy, drugs and more invasive interventions, need to be considered within a broader personalised management strategy, including self-management

Substantial evidence shows interactions between host genetics and gut microbiota, with microbial composition and specific taxa abundances being heritable traits [179, 180]

Twenty-seven patients received acetyl-l-carnitine at a dose of 500 mg twice daily for 10 days intramuscularly followed by the oral intake of 500 mg for 50 days (arm A)

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