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Although some studies confirm the feasibility of exempting patients who achieve pCR after neoadjuvant systemic therapy under rigorous evaluation using ultrasound or MRI, 323,326,327 this approach is constrained by regional development levels and technological disparities

6,73 Efficacy in patients under age 50 has not been as comprehensively studied, but clinical trials have demonstrated favorable safety profiles for famciclovir, valacyclovir, and acyclovir in children

PubMed Rosen, R.C., Diamond, L.E., Earle, D.C., Shadiack, A.M., & Molinoff, P.B