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Underestimation of the PentosePhosphate Pathway in Intact Primary Neurons as Revealed by Metabolic Flux Analysis

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In 2015, Kalkote and Chavan reported the use of Mn(iii)-salen-catalyzed oxidative kinetic resolution as the key step in obtaining enantiomerically pure R - and S -ALA (Scheme 20)

The oxidative branch of the PPP consists of three irreversible steps and is regulated by cellular NADPH levels

In contrast, metabolic remodeling in tumor cells is advantageous for cancer cell growth and proliferation, driving tumor development and becoming a hallmark of cancer