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That argument was an early argument that people tried to say, Well, if you do it orally, youre going to get a better response. Well, no, thats not true

For example, UK SmPCs for GLP-1 receptor agonists advise caution in patients with a history of pancreatitis or gallbladder disease, and include precautionary guidance regarding thyroid symptoms (such as a neck mass, difficulty swallowing, or hoarseness) that should be reported promptly

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There is a high incidence of post-injection pain for approximately twenty four hours in many cases and the efficacy has been shown to be only of short term benefit