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Furthermore, excitotoxicity due to the disruption of glutamatergic neurotransmission with the perturbations in the levels of catecholamine neurotransmitters resulting from MSG contributed to the appearance of various behavioral deficits including, impaired memory and cognitive function, together with anxiety-like behaviors and hyperactivity, which are core symptoms of ADHD (Rosa et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Bockwoldt M., Houry D., Niere M., Gossmann T.I., Reinartz I., Schug A., Ziegler M., Heiland I

We circumvented the need for CYP-mediated bioactivation of AQ and DEAQ by exposing the cells to the synthetic AQ-QI and DEAQ-QI, the reactive metabolites of AQ

SMURF1, Smad ubiquitylation regulatory factor-1