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COX-1 is constitutively expressed in almost all tissues, while COX-2 appears to only be constitutively expressed in the brain, kidney, bones, reproductive organs, and some neoplasms (e.g., colon and prostate cancers)

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The BR compounds can (antioxidant phytochemicals, iron, vitamin A and vitamin B6) protect the liver against the oxidative stress and inflammation and increase regular detoxification activity (173)

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404,405 In particular, reduced renal excretion leads to abnormal plasma adipokines levels including leptin and adiponectin in CKD patients

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Many people live with low B12 levels without realizing it, chalking up their symptoms to stress or lack of sleep

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