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If the viral protein(s) important to provide protection from infection or disease, and thus for inclusion in a vaccine (that is, the vaccine antigen), is known the availability of coding sequences for this viral protein(s) suffices to start vaccine development, rather than having to depend on the ability to culture the virus

Pathogenic mechanisms of autoantibodies in autoimmune diseases include interaction with cell surface receptors, cell surface binding and lysis, immune complex-mediated damage, binding to extracellular molecules, and autoantibody transfer across the placenta [321]

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13a, top), fused to the HIV-1 TAT protein transduction domain 48-59 (PTD