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In summary, the key interactions to consider are pyridoxines reduction of levodopa and anticonvulsant efficacy, niacinamides additive effects on blood pressure, blood sugar, and gout management, and the potential need for B-vitamin repletion in patients on certain medications (diuretics, isoniazid, etc.)

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BV has been shown to boost serotonin levels in the spinal cord and relieve cold allodynia in rats treated with oxaliplatin via activating spinal 5-HT3 receptors (Kim WooJin et al., 2016)