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JAMA 322 (9), 868886

Ni-enzymes are most widely used in anaerobic Bacteria and Archaea, which reflects the fact that Ni was prevalent in ancient environments (Hausinger, 2022)

If the stress is too severe or prolonged, the UPR can shift from a protective role to triggering apoptosis, in order to eliminate the affected cell and prevent damage (Spencer and Finnie, 2020)