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Conclusion: The PNPLA3 I148M oe reprograms macrophage metabolism because of reduced mitochondria number and/or mitochondrial dysfunction, thus affecting their phagocytotic capacity

Rationale and design of REDUCE-IT: Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial

Signal 8, 23

The secondary endpoints include achievement of 20% weight reduction, relative change in body weight, change in waist circumference, change in HbA1c, change in systolic blood pressure, change in the quality of life (IWQOL-Lite-CT), and change in short-form physical functioning score (SF-36v2)

Hum Behav Emerg Technol