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On the other hand, the accumulation of AGEs can bind to RAGE in kidney cells, which further leads to the intracellular inflammation and oxidative stress signaling pathways, such as nuclear factor-B (NF-B), phosphatidylinositide 3-kinase/protein kinase B (PI3K/Akt) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), etc

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