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The harsh environment of the stomach, filled with hydrochloric acid and digestive enzymes, can break down the glutathione molecule before it ever reaches the small intestine

IECs may utilize glucose generated from acetyl CoA by the oxidative phosphorylation of pyruvate under typical conditions

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In this case, the enzyme -glutamylcyclotransferase catalyzes the conversion of -glutamyl-L-cysteine to 5-oxoproline, favoring the occurrence of 5-oxoprolinuria, chronic metabolic acidosis and neurological disorders (Figure 2) [22]

Frontiers in Pharmacology, 12, 627533.