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Considering the MDCKII cells as a model of polarized epithelia arising from canine renal tubules, the direction of MeHg permeability across this monolayer fully correlates with the older experiment demonstrating rapid transport of MeHg across the tubular epithelium of the perfused proximal tubule in rabbits (Zalups and Barfuss 1993)

After being taken up, Fe3+ is reduced to Fe2+ in endosomes by the six-transmembrane epithelial antigen of prostate 3 (STEAP3), and then it is transported into the cytosol and free mitochondrial iron pools by solute carrier family 11 member 2(SLC11A2) ( 2+ can cause excessive lipid ROS accumulation through the Fenton reaction and can increase to activate nonheme iron-based arachidonate lipoxygenases (ALOXs) and nicotinamide adenine dinucleotide phosphate oxidases (NOXs), thereby promoting destructive lipid peroxidation ( 2+ is the degradation of hemoglobin mediated by haem oxygenase 1 (HMOX1)

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