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Genetic mutations that cause such a profound change in a protein that the result is death or non-viability of the organism are called lethal mutations

10.13748/j.cnki.issn1007-7693.2013.06.009 155 ZhangJ

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Zheng B, Albrecht U, Kaasik K, Sage M, Lu W, Vaishnav S, Li Q, Sun ZS, Eichele G, Bradley A, Lee CC (2001) Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock

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