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A retrospective analysis of 9479 referrals to multi-national liver transplant units gave an event rate of 3.3 million treatment years for non-overdose paracetamol as the aetiology for acute liver failure requiring transplant

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Caution is advised in patients with Leber optic atrophy, a genetic disorder caused by chronic cyanide intoxication (such as from smoking, alcohol or some plants), against the use of cyano-B12 due to its cyanide moiety, whilst hydroxo-B12 is a cyanide antagonist and can therefore be used in these patients

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Morphometric analysis showed that labeling for GSH was mainly associated with bacteroids and that the amount of label in the peribacteroid space remained constant throughout bacteroid differentiation (Table 2)