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JAMA 2011;305:21734

Indeed, several studies have reported that immunosuppression induced by exercise excess can increase the risk of infections and the development or aggravation of overtraining syndrome (Reference Gleeson, Pyne and Elkington76,Reference Edouard, Junge and Sorg77)

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doi: 10.1016/j.bbrc.2016.11.017 78 FuscoRSiracusaRGenoveseTCuzzocreaSDi PaolaR

KO, 1.58 0.08) groups, as compared to WT mice