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The increased hydrolysis of bilirubin conjugates in the newborn is enhanced by high mucosal -glucuronidase activity and the excretion of predominantly monoglucuronide conjugates (in the newborn) rather than diglucuronides (in the adult)

The anticonvulsant, phenytoin, has been shown to inhibit the intestinal absorption of folate, and several studies have associated decreased folate status with long-term use of the anticonvulsants, phenytoin, phenobarbital, and primidone (214)

In humans, taurine levels can fluctuate between 1 and 20 mol/g, with plasma concentrations typically ranging from 42 to 156 mol/L

The authors, with the aim of mimicking physiological methanol toxicity in humans, and investigating the role of aspartame-derived methanol, investigated the effects of aspartame in conditions of folate deficiency (by pretreatment with methotrexate) in rodents

Samples were diluted 100-fold, applied to copper grids, and stained using uranyl acetate at a concentration of 2% w/v