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Comparative and integrative metabolomics reveal that S-nitrosation inhibits physiologically relevant metabolic enzymes

The biosynthesis of CoQ10 is regulated by the MVA pathway in which acetyl-CoA is converted into 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA), followed by the synthesis of MVA from HMG-CoA, isopentenyl pyrophosphate (IPP) from MVA, and the final isoprenoid side chain of CoQ10 from IPP

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9, 10, 11, 12, 13, 14, 15, 27, 35 As Panza et al