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Among the currently known ionotropic and metabotropic glutamate receptors, NMDAR play an important role in allowing excess Ca 2+ inward flow, leading to ischemic cell death (Mao et al., 2022)

Figure 4C and S5A show a clear interaction between NQO1 and TBK1

Cerebrospinal fluid lactate and pyruvate concentrations and their ratio

compositions or formulations of the disclosure may be adapted to deliver a prescribed dosage of one or more therapeutic agents to a cell, a group of cells, an organ or tissue, an animal or a human