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A 2015 study in Cell Metabolism found that it plays a role in regulating blood sugar and metabolism, and that it can mimic some of the metabolic benefits of exercise in animal models

B12 deficiency causes fatigue, anemia, and neurologic symptoms, and is more common in older adults, vegans, and those with malabsorption conditions

Correcting the deficiency does not burn fat directly but it removes a genuine obstacle to the lifestyle changes that do

This is because B12 in this form has low bioavailability with absorption typically around ~1-2%

Regular retesting intervals allow for treatment optimization and ensure that therapeutic blood levels are maintained over time